The first half: Town made a perfect start when Lucy O'Brien pounced on a rebound in just the second minute after Plymouth goalkeeper Lily Felgate failed to deal with Natasha Thomas' low cross.
Thomas doubled the advantage in the 25th minute, powering home a header from Sophie Peskett's cross on the right.
The Blues continued to dominate throughout the first half, with Megan Wearing nearly adding a third when her looping header from an O'Brien corner struck the crossbar.
Town goalkeeper Natalia Negri wasn't required to make a save in the first half, highlighting Town's dominance.
The second half: Peskett, a constant threat down the right, extended Town's lead in the 57th minute, turning home the rebound after Felgate could only parry Ella Rutherford's fierce strike.
The Blues could have scored more, with Maisy Barker setting up Peskett in the 72nd minute only for the winger's effort to be tipped onto the post.
Plymouth's afternoon worsened when Panagiota Papaioannou received a second yellow card in the 80th minute for a foul on Ruby Seaby, reducing the visitors to 10 players.
The Pilgrims did manage a consolation goal two minutes later when Charlotte Whitmore intercepted a loose pass from Negri and coolly finished into an empty net from outside the box.
What's next: Town Women, now top of the league as they chase promotion, return to action at the Martello Ground against Gwalia United on Sunday, 30 March.
The bottom line: Ipswich were a class above their opponents, creating numerous chances from both wings throughout the match and could have scored considerably more than their three goals in front of an enthusiastic home crowd.
